Last data update: May 06, 2024. (Total: 46732 publications since 2009)
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Query Trace: Gerkowicz SA[original query] |
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Assisted reproductive technology with donor sperm: National trends and perinatal outcomes
Gerkowicz SA , Crawford SB , Hipp HS , Boulet SL , Kissin DM , Kawwass JF . Am J Obstet Gynecol 2017 218 (4) 421 e1-421 e10 BACKGROUND: Information regarding use of donor sperm in assisted reproductive technology, as well as subsequent treatment and perinatal outcomes, remains limited. Outcome data would aid patient counseling and clinical decision-making. OBJECTIVES: To report national trends in donor sperm utilization and live birth rates of donor sperm assisted reproductive technology cycles in the United States, and to compare assisted reproductive technology treatment and perinatal outcomes between cycles using donor and non-donor sperm. We hypothesize these outcomes to be comparable between donor and non-donor sperm cycles. STUDY DESIGN: Retrospective cohort study using data from all United States fertility centers reporting to the Centers for Disease Control and Prevention's National Assisted Reproductive Technology Surveillance System, accounting for approximately 98% of assisted reproductive technology cycles (definition excludes intrauterine insemination). The number and percentage of assisted reproductive technology cycles using donor sperm and rates of pregnancy, live birth, preterm birth (<37 weeks), and low birth weight (<2500g) were the primary outcomes measured. Treatments assessed include use of donor versus non-donor sperm. The trends analysis included all banking and fresh assisted reproductive technology cycles using donor and autologous oocytes performed between 1996 and 2014 (n=1,710,034). The outcomes analysis was restricted to include only fresh autologous cycles performed between 2010 and 2014 (n=437,569) in order to focus on cycles with a potential outcome and cycles reflective of current practice, thereby improving the clinical relevance. Cycles cancelled prior to retrieval were excluded. Statistical analysis included linear regression to explore polynomial trends and log-binomial regression to estimate relative risk for outcomes among cycles using donor and non-donor sperm. RESULTS: Of all banking and fresh donor and autologous oocyte assisted reproductive technology cycles performed between 1996 and 2014, 74,892 (4.4%) used donor sperm. In 2014, 7,351 assisted reproductive technology cycles using donor sperm were performed, as compared to 1,763 in 1996 (6.2% vs. 3.8% of all cycles). Among all autologous oocyte cycles performed between 2010 and 2014, the live birth rate was lower for donor sperm (27.9%) than non-donor sperm cycles (32.5%); however, after adjustment for maternal age, donor sperm use was associated with an increased likelihood of live birth (adjusted relative risk=1.06, 95% confidence interval=1.01-1.10). Per transfer, there was no significant difference in live birth rates for donor versus non-donor sperm (31.9% vs. 36.8%; adjusted relative risk =1.04, 95% confidence interval =0.998-1.09). Per singleton live birth there was no significant difference in preterm birth (11.5% vs. 11.8%; adjusted relative risk =0.98, 95% confidence interval =0.90-1.06); however, low birth weight delivery was slightly lower in donor sperm cycles (8.8% vs. 9.4%; adjusted relative risk =0.91, 95% confidence interval =0.83-0.99). CONCLUSIONS: Donor sperm use in assisted reproductive technology has increased in the United States, accounting for approximately 6% of all assisted reproductive technology cycles in 2014. Assisted reproductive technology treatment and perinatal outcomes were clinically similar in donor and non-donor sperm cycles. |
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